Table 2.

Scoring criteria for immunohistochemical localization

Molecule	Immunolocalization for evaluation	Score of immunoreactivity
		0	1	2	3
Ceruloplasmin	Luminal cellular surface	—	Weakly positive, a few follicles	Strongly positive, focal follicular populations	Strongly positive, majority of follicles
Ccnb1	Cytoplasm	—	Weakly positive, a few cells	Weakly positive, majority of cells	Strongly positive, majority of cells
Cdc2	Cytoplasm and nucleus	—	1–10 cells/400× field	10–30 cells/400x field	> 30 cells/400× field
Thyroglobulin	Cytoplasm	—	< 20% cells	20–70% cells	> 70% cells
Pvrl3	Intercellular membrane	—	Focally positive	Entirely positive	Not applied
Id3	Nucleus	—	Weakly positive, a few cells	Weakly positive, majority of cells	Strongly positive, majority of cells

Ccnb1, Cyclin B1; Cdc2, cell division cycle 2; Id3, inhibitor of DNA binding 3; Pvrl3, poliovirus receptor‐related 3.