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. 2011 Jan 10;102(3):597–604. doi: 10.1111/j.1349-7006.2010.01817.x

Figure 5.

Figure 5

 Inhibition of breast cancer growth by KO‐202125 in mouse xenograft models. MDA‐MB‐231 cells were engrafted s.c. into nude mice. When the tumor reached a width of 2.5–5 mm, the mice were treated daily p.o. with corn oil or KO‐202125 for 28 days (day 0 set as the time of starting drug treatment). The dose of KO‐202125 is as follows: low, 0.078 mg/kg; medium, 0.39 mg/kg; high, 1.95 mg/kg. The tumor volume was measured as described in the Materials and Methods. Results are from at least four animals and presented as mean ± SD. P values indicate statistical significance of inhibition of tumor growth by KO‐202125 (post‐hoc test using Scheffe). *P < 0.005.