Table 1.

Basic characteristics of 643 Japanese alcoholic men who participated in this study

	Esophageal dysplasia (n = 126)	Esophageal SCC (n = 42)	Oropharyngo‐ laryngeal SCC (n = 14)	Esophageal/ oropharyngo‐ laryngeal SCC (n = 49)	Controls(n = 437)
Age (years)
50–59	44%	43%	71%	47%	53%
60–69	41%	43%	21%	41%	37%
70–79	15%	14%	7%	12%	9%
P, vs. controls †	0.073	0.34	0.42	0.58	–
Alcohol intake (drinks/day) ‡
<6	21%	26%	7%	22%	16%
6–8.9	31%	43%	71%	47%	30%
9–11.9	22%	17%	7%	14%	28%
12 +	26%	14%	14%	16%	25%
P, vs. controls §	0.59	0.068	0.016	0.027	–
Smoking (cigs/day)
<20	39%	19%	21%	16%	44%
20–29	33%	52%	50%	51%	35%
30 +	29%	29%	29%	33%	22%
P, vs. controls §	0.078	0.003	0.34	0.0004	–
ALDH2genotype	(n = 86) ††	(n = 42)	(n = 14)	(n = 49)	(n = 273) ††
*1/*1	83%	57%	50%	57%	91%
*1/*2	17%	43%	50%	43%	9%
*2/*2	0.0%	0.0%	0.0%	0.0%	0.0%
P, vs. controls §	0.072	<0.0001	< 0.0001	< 0.0001	–
P for HWE ¶	1.0	0.16	0.51	0.091	1.0

^† Fisher's exact test;

^‡ 1 drink = 12 g ethanol;

^§ Cochran–Mantel–Haenszel test for homogeneity adjusted for age;

^¶ Exact P‐value for deviation from the Hardy–Weinberg equilibrium (HWE);

^†† Genotype data were available only for those admitted to the Center on Tuesday or Thursday. –, not applicable.