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Possible mechanism of action of reveromycin A (RM‐A) in osteoclasts. The specific sensitivity of osteoclasts to RM‐A is due to their acidic microenvironment, which increases cell permeability of RM‐A by suppressing the dissociation of protons from their carboxylic acid moieties. In osteoclasts, RM‐A induces apoptosis through inhibition of isoleucyl‐tRNA synthetase (IleRS) activity.
