Figure 1.

In the interferon‐α (IFNα)‐sensitive and ‐resistant lines, known IFN signaling molecules, STAT1, STAT2, Jak1, Tyk2, and ISGF3γ, are expressed with no apparent difference between cell lines (a). Sequential Western blot analyses show that IFN receptor (IFNR) was continuously expressed and that expression of ISGF3γ was increased after IFNα treatment. Additionally, it was confirmed that phosphorylation of STAT1 (STAT1‐P) is observed at 3 h after IFNα treatment equally in IFNα‐sensitive and ‐resistant lines (b).