Expression of up‐regulated genes in interferon‐α (IFNα)‐sensitive lines was higher after IFNα treatment than before treatment. MLLT3 (a) was preserved after IFNα treatment, and ADFP (b), MTUS1 (c), and MITF (e) increased in the early stage after IFNα treatment while up‐regulation of PME‐1 (d) after IFNα treatment was observed in a relatively late phase. Y‐axis and X‐axis indicate relative gene expression level and time after IFNα treatment, respectively. On the other hand, TNNT1 (f) and MLF1 (g) were up‐regulated in IFNα‐resistant lines, and TNNT1 was elevated longer after IFNα treatment than MLF1. Y‐axis and X‐axis indicate relative gene expression level and time after IFNα treatment, respectively.