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Various types of methylation in a promoter CGI. When the core region (shown by brackets)* is methylated, transcription of the downstream gene is blocked (d, e). However, even if non‐core regions are methylated, transcription is not blocked (b). ‘Seeds of methylation’ (c) is drawing attention as a precursor for dense methylation (e). Open lollipops show unmethylated CpG sites, and closed lollipops show methylated CpG sites.
