Combining kallistatin gene therapy and meloxicam shows a stronger effect in suppressing tumor growth compared to monotherapies. HepG2 hepatomas were established. When the tumors reached approximately 100 mm3 (indicated by a vertical arrow), they received pcDNA3.1 (control), Kalli‐pcDNA3.1, meloxicam, or Kalli‐pcDNA3.1 + meloxicam treatments. The sizes (mm3) of tumors were recorded. †Significant difference in tumor volumes compared to control. Significant difference in tumor volumes compared to Kalli‐pcDNA3.1 treatment (‡), and meloxicam treatment (§).