Table 3.
Association between anticipatory nausea (AN) and psychological distress, needs, and quality of life (QOL)
| AN (+) (n = 22) | AN (−) (n = 192) | P | P† | |
|---|---|---|---|---|
| Psychological distress (HADS) | Mean (SD) | |||
| Anxiety | 7.5 (3.9) | 5.1 (3.6) | 0.004 | 0.005 |
| Depression | 8.2 (3.5) | 5.9 (3.8) | 0.007 | 0.010 |
| Total | 15.7 (6.7) | 11.0 (6.9) | 0.003 | 0.004 |
| Needs (SCNS‐SF34) | ||||
| Psychological | 31.5 (8.1) | 25.1 (10.2) | 0.005 | 0.007 |
| Health system and information | 30.0 (9.2) | 27.4 (10.0) | 0.240 | 0.200 |
| Physical and daily living | 12.7 (4.1) | 10.5 (4.2) | 0.020 | 0.030 |
| Patient care and support | 12.8 (4.8) | 10.7 (4.1) | 0.030 | 0.030 |
| Sexuality | 6.1 (3.4) | 4.4 (2.3) | 0.030 | 0.002 |
| QOL (EORTC QLQ C‐30) | ||||
| Global health status | 35.6 (21.5) | 54.9 (23.0) | <0.001 | 0.001 |
| Physical functioning | 73.3 (19.4) | 80.3 (17.6) | 0.080 | 0.060 |
| Role functioning | 53.8 (19.2) | 68.3 (28.5) | 0.020 | 0.050 |
| Emotional functioning | 66.3 (19.5) | 78.1 (19.9) | 0.009 | 0.020 |
| Cognitive functioning | 64.4 (24.3) | 75.7 (21.2) | 0.020 | 0.020 |
| Social functioning | 57.6 (28.0) | 73.5 (23.4) | 0.004 | 0.010 |
†P, multivariate analysis adjusting for age, sex, and performance status. EORTC QLQ‐C30, European Organization for the Research and Treatment of Cancer QLQ‐C30 questionnaire; HADS, Hospital Anxiety and Depression Scale; SCNS‐SF34, Short‐form Supportive Care Needs Survey questionnaire.