Table 2a.
Adverse events occurring in 20% or more of patients
| Adverse event | SR29142 | |||
|---|---|---|---|---|
| 0.15 mg/kg (n = 25) | 0.20 mg/kg (n = 25) | |||
| All gradesn (%) | Grade 3/4n (%) | All gradesn (%) | Grade 3/4n (%) | |
| White blood cells decreased | 24 (96) | 22 (88) | 22 (88) | 21 (84) |
| Neutrophil count decreased | 22 (88) | 22 (88) | 19 (76) | 19 (76) |
| Alopecia | 20 (80) | 0 (0) | 18 (72) | 0 (0) |
| Lymphocyte count decreased | 16 (64) | 15 (60) | 18 (72) | 15 (60) |
| Nausea | 12 (48) | 0 (0) | 15 (60) | 1 (4) |
| Constipation | 10 (40) | 4 (16) | 11 (44) | 3 (12) |
| Aspartate aminotransferase increased | 6 (24) | 0 (0) | 11 (44) | 1 (4) |
| Hemoglobin decreased | 11 (44.0) | 4 (16) | 6 (24) | 0 (0) |
| Platelet count decreased | 8 (32) | 4 (16) | 9 (36) | 3 (12) |
| Alanine aminotransferase increased | 7 (28) | 1 (4) | 8 (32) | 1 (4) |
| Anorexia | 7 (28) | 1 (4) | 8 (32) | 1 (4) |
| Malaise | 7 (28) | 0 (0) | 8 (32) | 0 (0) |
| Vomiting | 6 (24) | 0 (0) | 9 (36) | 0 (0) |
| Diarrhea | 8 (32) | 0 (0) | 4 (16) | 0 (0) |
| Hyperglycemia | 6 (24) | 2 (8) | 5 (20) | 1 (4) |
| Pyrexia | 5 (20) | 0 (0) | 6 (24) | 1 (4) |
| Stomatitis | 3 (12) | 0 (0) | 8 (32) | 1 (4) |
| Blood bilirubin increased | 7 (28) | 0 (0) | 3 (12) | 0 (0) |
| Blood lactate dehydrogenase increased | 5 (20) | 0 (0) | 5 (20) | 1 (4) |