Table 4.
Pharmacokinetic parameters of SR29142
| SR29142† | ||||||
|---|---|---|---|---|---|---|
| 0.15 mg/kg (n = 11) | 0.20 mg/kg (n = 10) | |||||
| Mean | SD | CV (%) | Mean | SD | CV (%) | |
| Day 1 | ||||||
| AUC0–24 (ng.h/mL) | 45 653 | 7544 | 17 | 59 333 | 15 849 | 27 |
| Ceoi (ng/mL) | 3734 | 1081 | 29 | 4239 | 1556 | 37 |
| Day 5 | ||||||
| AUC0–24 (ng.h/mL) | 48 210 | 9660 | 20 | 65 154 | 22 713 | 35 |
| t½z (h) | 22.5 | 5.8 | 26 | 16.1 | 5.6 | 35 |
| Ceoi (ng/mL) | 3948 | 710 | 18 | 5126 | 1468 | 29 |
| Cmin (ng/mL) | 852 | 269 | 32 | 1033 | 494 | 48 |
†
SR29142 was administered once daily for 5 consecutive days. AUC0–24, area under the concentration–time curve for 0–24 h; Ceoi, plasma concentration of end of infusion; Cmin, minimum plasma concentration; CV, coefficient of variance; SD, standard deviation; t1/2z, terminal elimination half‐life.