Figure 1.

 Apical extrusion and basal protrusion formation of RasV12‐expressing cells surrounded by normal epithelial cells. Fluorescently labeled MDCK‐pTR GFP‐RasV12 cells (CMTPX) are mixed with non‐transformed MDCK cells (a,c) or MDCK‐pTR GFP‐RasV12 cells (b). Images are extracted from a representative time‐lapse analysis. Scale bar = 20 μm. (a,b) Red arrows indicate fluorescently labeled RasV12 cells. (c) Images are captured at 50‐min intervals. Black arrow and white arrows indicate RasV12 cell surrounded by non‐transformed cells and protrusions, respectively. (Adapted from Hogan et al., 4 with permission, 1, 3.)