Table 1.

 Interactions between normal and transformed epithelial cells in vertebrates, except where hematopoietic stem and precursor cells were used for analyses (†)

	Mutations	Phenomena (reference)	Signaling pathways involved
Cell culture	Ras	Apical extrusion or basal protrusion formation of Ras‐transformed cells (4)	MAPK, Myosin‐II, Cdc42, ROCK
	Src	Apical extrusion of Src‐transformed cells (5)	MAPK, Myosin‐II, FAK
	Mahjong	Apoptosis of Mahjong‐knockdown cells (6)	JNK
	Scribble	Apoptosis of Scribble‐knockdown cells (Norman et al., unpublished data; Medical Research Council, Laboratory for Molecular Cell Biology, London, UK)	p38MAPK
In vivo
Zebrafish	Src	Apical extrusion of Src‐transformed cells (5)	Unknown
Mice	Minute	Elimination of Minute‐knockout cells (37)	Unknown
	p53†	Cell competition between wild‐type and p53 mutant cells (30)	Unknown