Table 1.
Interactions between normal and transformed epithelial cells in vertebrates, except where hematopoietic stem and precursor cells were used for analyses (†)
Mutations | Phenomena (reference) | Signaling pathways involved | |
---|---|---|---|
Cell culture | Ras | Apical extrusion or basal protrusion formation of Ras‐transformed cells (4) | MAPK, Myosin‐II, Cdc42, ROCK |
Src | Apical extrusion of Src‐transformed cells (5) | MAPK, Myosin‐II, FAK | |
Mahjong | Apoptosis of Mahjong‐knockdown cells (6) | JNK | |
Scribble | Apoptosis of Scribble‐knockdown cells (Norman et al., unpublished data; Medical Research Council, Laboratory for Molecular Cell Biology, London, UK) | p38MAPK | |
In vivo | |||
Zebrafish | Src | Apical extrusion of Src‐transformed cells (5) | Unknown |
Mice | Minute | Elimination of Minute‐knockout cells (37) | Unknown |
p53† | Cell competition between wild‐type and p53 mutant cells (30) | Unknown |