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A model that shows a novel relation between peroxiredoxin (Prdx) gene expression and Ets/HMGB1 transcription system. Oxidative stress induces the expression of Ets transcription factors. Then, Ets transcription factors induce both Prdx1 and Prdx5 expression via binding to Ets binding site. HMG proteins enhance the DNA binding ability of Ets transcription factors and function as a coactivator. Increased Prdxs lead to resistance against oxidative stress.
