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. 2009 Feb 26;100(5):914–919. doi: 10.1111/j.1349-7006.2009.01117.x

Figure 2.

Figure 2

Immunohistochemical analysis of stanniocalcin 2 (STC2) in prostate cancer tissues. Immunoreactivity with anti‐STC2 antibody was observed in castration‐resistant prostate cancers (CRPCs) and castration‐naïve prostate cancers (CNPCs) with high Gleason scores (GS), exhibiting strong positive immunostaining in the cytoplasm of prostate cancer cells. (a) The representative picture of CRPC (×200); (b) the representative picture of CNPC with GS 10 (×200); (c) the representative picture of CNPC with GS 7 (×200). Adjacent normal prostatic epithelium revealed very weak or no signal for STC2 ([b,c] arrowheads). (d) Correlation between STC2 immunohistochemical (IHC) score and GS in CNPCs. There were significant differences in STC2 IHC scores between the GS 2–6 group (n = 12) and the GS 8–10 group (n = 8), and between the GS 7 (n = 33) and GS 8–10 groups (Mann–Whitney U‐test with Bonferroni method; P = 0.0006 and P = 0.0004, respectively).