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Spatial and temporal heterogeneity of the epithelial–mesenchymal transition (EMT). Cancer cells undergoing EMT are expected to be only a small proportion of primary tumor tissues. EMT cells transported to metastatic sites are expected to undergo and mesenchymal–epithelial transition (MET). Therefore, the spatial and temporal heterogeneity of EMT/MET severely restricts the ability of pathologists to detect cancer cells undergoing EMT in histological sections.
