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. 2009 Apr 21;100(8):1460–1467. doi: 10.1111/j.1349-7006.2009.01194.x

Figure 2.

Figure 2

Vacuolar H+‐ATPase (V‐ATPase) inhibitors overcome anti‐apoptotic Bcl‐2/Bcl‐xL against anticancer drugs. Human small cell lung carcinoma Ms‐1 cell lines transfected with (a) Bcl‐xL or (b) Bcl‐2 were treated with destruxin E (DE), bafilomycin A1 (BMA), or concanamycin B (CMB) in combination with various anticancer drugs as indicated for 48 h. CPT, camptothecin, 3 µg/mL; INM, inostamycin, 0.1 µg/mL; TXL, taxol, 30 ng/mL; VBL, vinblastine, 10 ng/mL. (c) Ms‐1/neo cells were treated with DE or BMA in combination with various concentrations of CPT, TXL, or INM for 48 h. Cell viability was assessed by trypan blue dye exclusion assay. Values are the means of three samples; bars, SD.