Figure 4.

Postulated roles for menin in transcriptional repression and activation. In this model, menin represses pro‐cell growth genes by recruiting a general corepressor mSin3A and histone deacetylase (HDAC) to specific transcription factor (TF) binding sites, thus promoting histone deacetylation (upper). On the other hand, menin activates transcription of genes involved in cell growth inhibition and cell differentiation by recruiting lens epithelium‐derived growth factor (LEDGF) and histone methyltransferase (HMT) to specific TF binding sites, thus promoting histone methylation (lower).