Table 2.

Molecular function of menin deduced from its binding partners

Binding partners	Suggested menin function	References
JunD †	Transcriptional repression	28, 29, 30
Nuclear factor‐κB †	Transcriptional repression	31
Pem †	Transcription, spermatogenesis	34
Smad1, Smad3, Smad5, Runx2	Transcriptional repression, transforming growth factor‐β signal transduction, cell division, osteoblastic differentiation	32, 33
mSin3A, histone deacetylase	Transcriptional repression through histone deacetylation, DNA repair	30, 39
Mixed‐lineage leukemia oncoprotein–histone methlytransferase complex, lens epithelium‐derived growth factor	Transcriptional activation through histone methylation, hematopoietic cell differentiation	35, 36, 37, 38, 39, 40, 41
Estrogen receptor α †	Transcriptional activation	42
Fanconi anemia complementation group D2	DNA repair	45
Check point suppressor 1 †	Transcriptional repression, DNA damage response	48
32‐kDa subunit of replication protein A †	Cell division, DNA repair	44
Activator of S‐phase kinase	Cell division	52
Glial fibrillary acidic protein, vimentin	Cell division	27
Non‐muscle myosin type II‐A heavy chain †	Cell division	51
nm23β †	GTPase	49, 50

^† Molecules demonstrated to bind directly to menin. The binding of the molecules without this symbol may be indirect.