Table 4.
Summary of the genes upregulated or downregulated more than five‐fold by S100A4
| Gene upregulated | Fold change | Gene downregulated | Fold change | ||||
|---|---|---|---|---|---|---|---|
| S100A2 | S100A4 | S100A2 | S100A4 | ||||
| Adehesion | Integrin, beta 3 | 4.9 | 7.5 | Adhesion | Claudin 8 | 0.63 | 0.21 |
| Apoptosis | Endonuclease G | 4.8 | 8.5 | Desmocollin 2 | 0.1 | 0.06 | |
| Exonuclease NEF‐sp. | 4.3 | 7.2 | Apoptosis | Cylindromatosis(turban tumor syndrome) | 0.72 | 0.05 | |
| Cell cycle | Cyclin‐dependent kinase 6 | 7.7 | 7.4 | Cell cycle | CDC14 cell division cycle14 homolog A | 0.85 | 0.21 |
| Channel | ATP synthase, H + transporting, subunit c | 2.2 | 6.5 | Cyclin D2 | 0.45 | 0.19 | |
| Solute carrier family 11, member 1 | 9 | 5.7 | Cyclin D1 | 0.14 | 0.14 | ||
| Mucolipin 3 | 5.6 | 5.8 | Channel | Amiloride‐sensitive cation channel 2, neuronal | 0.58 | 0.25 | |
| Solute carrier family 7, member 8 | 2.9 | 5.4 | Solute carrier family 27, member 3 | 0.21 | 0.21 | ||
| Cytoskeleton | Microtubule‐associated protein 1A | 8 | 7.7 | Potassium inwardly rectifying Channel, member 6 | 0.29 | 0.2 | |
| Villin 2 (ezrin) | 3.9 | 7.3 | Solute carrier family 34, member 1 | 0.21 | 0.19 | ||
| Parvin, alpha | 3.7 | 6.5 | Solute carrier family 1, member 3 | 0.15 | 0.18 | ||
| Keratin, cuticle, ultrahigh sulfur 1 | 1.3 | 6.2 | ATP‐binding cassette, subfamily A, member 1 | 0.77 | 0.15 | ||
| ECM | Laminin, alpha 2 | 1.9 | 6.2 | Solute carrier family 25, member 14 | 1 | 0.07 | |
| Enzyme | Glutathione transferase zeta 1 | 2.9 | 9.7 | Cytokine | Eosinophil chemotactic cytokine | 0.12 | 0.16 |
| Peptidyl arginine deiminase, type IV | 1.1 | 8.1 | Cytoskeleton | Annexin A10 | 0.69 | 0.18 | |
| GalNAc‐T6 | 4.9 | 6.6 | Mucin | Mucin 3B | 1 | 0.21 | |
| MAP/microtubule affinity‐regulating kinase 2 | 5.3 | 6.5 | Enzyme | Adenosine deaminase, RNA‐specific, B2 | 0.31 | 0.23 | |
| Aldehyde dehydrogenase 4 family, member A1 | 6.9 | 6.4 | Histone deacetylase 9 | 0.72 | 0.23 | ||
| Hydroxyacid oxidase (glycolate oxidase) 1 | 3.7 | 5.8 | Hexosaminidase A (alpha polypeptide) | 0.22 | 0.23 | ||
| Pancreatic lipase‐related protein 1 | 4.2 | 5.7 | UDP‐Gal:betaGlcNAc beta1, 4‐galactosyltransferase | 0.67 | 0.22 | ||
| Ribonuclease, RNase A family, 4 | 5.6 | 5.6 | Formyltetrahydrofolate dehydrogenase | 0.98 | 0.2 | ||
| Serine palmitoyltransferase | 6.7 | 5.5 | Choline acetyltransferase | 0.16 | 0.18 | ||
| Heparanase | 2.5 | 5.4 | Proteinase | ADAMTS2 | 0.79 | 0.22 | |
| Tousled‐like kinase 1 | 4.5 | 5.3 | Receptor | Benzodiazapine receptor associated protein 1 | 0.23 | 0.25 | |
| Proteinase | Legumain | 8.7 | 7.4 | Leukotriene B4 receptor | 0.23 | 0.24 | |
| Receptor | G‐protein‐coupled receptor 6 | 2.2 | 10 | EphB4 | 0.93 | 0.22 | |
| Formyl peptide receptor‐like 1 | 1.3 | 6.5 | Adrenergic, alpha‐2C‐, receptor | 0.52 | 0.22 | ||
| Thy‐1 cell surface antigen | 6.4 | 6.3 | G protein‐coupled receptor 3 | 0.9 | 0.22 | ||
| CD1E antigen, e polypeptide | 2.4 | 5.8 | Cholinergic receptor, nicotinic, beta polypeptide 2 | 0.23 | 0.19 | ||
| EphB6 | 3.9 | 5.1 | Prostaglandin E receptor 3(subtype EP3) | 0.61 | 0.13 | ||
| Signal | Calmodulin‐like 3 | 9.21 | 15 | Pre T‐cell antigen receptor alpha | 0.07 | 0.12 | |
| Dual specificity phosphatase 7 (DUSP7) | 2 | 15 | Signal | PTK2B protein tyrosine kinase 2 beta | 0.35 | 0.22 | |
| Protein phosphatase 2 (PPP2R2B) | 2.7 | 13 | Guanine nucleotide binding protein, alpha 11 | 0.5 | 0.19 | ||
| Dihydropyrimidinase‐like 3 | 12 | 12 | TERF1 (TRF1)‐interacting nuclear factor 2 | 0.89 | 0.19 | ||
| BCR downstream signaling 1 | 0.63 | 8.9 | RAB40A, member RAS oncogene family | 0.08 | 0.18 | ||
| Mitogen‐activated protein kinase 4 (MAPK4) | 4.9 | 7.7 | G protein‐coupled receptor kinase‐interactor 2 | 0.27 | 0.15 | ||
| Protein phosphatase 1F (PPM1F) | 2.4 | 6.5 | Regulator of G‐protein signaling 3 | 0.82 | 0.13 | ||
| Dual‐specificity phosphorylation regulated kinase 2 | 6.2 | 6.1 | Interleukin 1 receptor accessory protein | 0.5 | 0.05 | ||
| Suppressor of cytokine signaling 1 (SOCS1) | 7.6 | 5.3 | Transcription | TAF6‐like RNA polymerase II | 0.73 | 0.25 | |
| Protein tyrosine phosphatase, receptor type, F | 4.4 | 5.2 | Nuclear factor of activated T‐cell 5 | 0.56 | 0.24 | ||
| TRAF interacting protein (TRIP) | 2.6 | 5.1 | MAX dimerization protein 1 | 0.49 | 0.23 | ||
| Transcription | cbfa2T1 (ETO/MTG8) | 19 | 15 | Snail homolog 1 (Drosophila) | 1.2 | 0.23 | |
| Zinc finger protein 42 | 1.3 | 6.6 | Interferon consensus sequence binding protein 1 | 0.72 | 0.19 | ||
| Runt‐related transcription factor 1 (RUNX1) | 1.1 | 6.3 | Zinc finger protein 36 (KOX 18) | 0.6 | 0.19 | ||
| SIN3 homolog B, transcriptional regulator | 3.4 | 5.7 | Paired box gene 3 | 0.15 | 0.15 | ||
| Paired box gene 8 | 4.6 | 5.7 | Snf2‐related CBP activator protein | 0.12 | 0.12 | ||
| Interferon regulatory factor 7 | 3.1 | 5.5 | Homeo box A10 | 0.12 | 0.1 | ||
| Homeo box B2 | 2.1 | 5.3 | Others | 5‐hydroxytryptamine (serotonin) receptor 1D | 0.46 | 0.24 | |
| Paired box gene 8 | 3.8 | 5.3 | Vacuolar protein sorting 33 A(yeast) | 0.91 | 0.24 | ||
| Estrogen receptor 1 | 1.1 | 5.2 | CD79A antigen | 0.57 | 0.24 | ||
| LIM protein | 6.9 | 5.2 | Tripartite motif‐containing 2 | 0.14 | 0.24 | ||
| Msh homeo box homolog 2 (Drosophila) | 4 | 5.1 | Neuron navigator 3 | 0.88 | 0.23 | ||
| Others | Metallothionein 3 | 13 | 13 | Gem (nuclear organelle) associated protein 4 | 0.82 | 0.23 | |
| Melanoma differentiation associated protein‐5 | 7.9 | 11 | Fibrinogen, A alpha polypeptide | 0.77 | 0.22 | ||
| Tissue inhibitor of metalloproteinase 3 | 0.86 | 8 | DEAD (Asp‐Glu‐Ala‐Asp) box polypeptide 17 | 0.5 | 0.2 | ||
| SP110 nuclear body protein | 0.51 | 7.8 | Semaphorin 3A | 0.75 | 0.2 | ||
| Apolipoprotein L, 6 | 4 | 7.7 | Beta‐transducin repeat containing | 0.17 | 0.2 | ||
| Hemoglobin, gamma G | 1.6 | 6.9 | Ewing sarcoma breakpoint region 1 | 0.22 | 0.2 | ||
| WNT1 inducible signaling pathway protein 1 (WISP1) | 1.1 | 6.9 | Lysosomal apyrase‐like protein 1 | 1.4 | 0.19 | ||
| Membrane‐spanning 4‐domains, member 6A | 3 | 6.1 | Apolipoprotein A‐II | 0.15 | 0.17 | ||
| Serine (or cysteine) proteinase inhibitor, member 9 | 2 | 5.7 | Interleukin 1 receptor antagonist | 0.7 | 0.17 | ||
| Abhydrolase domain containing 6 | 5.2 | 5.7 | Integral membrane protein 2C | 1.6 | 0.15 | ||
| Regenerating islet‐derived 1 alpha | 3.7 | 5.5 | Uromodulin | 0.74 | 0.15 | ||
| CD64 | 1.3 | 5.5 | Heat shock 70 kDa protein 4 | 0.95 | 0.13 | ||
| Complement component 1q receptor 1 | 4.6 | 5.1 | PR domain containing 2, with ZNF domain | 0.46 | 0.12 | ||
| Tissue inhibitor of metalloproteinase 2 | 4.4 | 5.1 | Fanconi anemia, complementation group F | 0.52 | 0.11 | ||
| XPA‐binding protein 2 | 0.9 | 0.11 | |||||
ECM, extracellular matrix.