Table 2.

Summary of PIK3CA mutations in oral squamous cell carcinoma

Exon	Nucleotide	Amino acid	Cell lines	Primary cases
9	G1624A	E542K*	0	2
9	G1633A	E545K*	1	1
9	A1634G	E545G	1	0
9	A1637T	Q546L	0	1
20	A3127G	M1043V	0	1
20	A3140G	H1047R*	1	1
20	G3145A	G1049S	0	1
20	G3145C	G1049R	0	1
Samples with mutations			3/14 (21.4%)	8/108 (7.4%)

^* A hot spot mutation previously reported to elevate kinase activity compared with the wild type.