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. 2008 Mar 28;99(4):683–688. doi: 10.1111/j.1349-7006.2008.00742.x

Figure 1.

Figure 1

Doxorubicin induces p53‐dependant luciferase expression in HCT116‐p53RE‐Luciferase cells in a dose‐dependant manner. (a) Stably transfected p53+/+ and p53−/– cells were incubated with various doses of doxorubicin and luciferase activity was measured after 24 h. (b) HCT116‐p53RE‐Luciferase p53−/– were infected with either Ad‐CMV‐p53 or Ad‐GFP (control) at a multiplicity of infection of 50. Luciferase expression was determined 24 h later. (NI: non‐infected cells). Columns: averaged luciferase activity (4 wells per condition); bars: standard error of the mean. Luciferase activity in Ad‐CMV‐p53 is compared to the non‐infected cells (P < 0.0001). NS: non‐significant.