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Table 1.

Median survival of mice after intraperitoneal inoculation of HSC45‐M2 tumor cells and injection of different activities of 213Bi‐immunoconjugates

Treatment Median survival following therapy 1 day after tumor cell inoculation Median survival following therapy 8 days after tumor cell inoculation
Days 95% confidence interval Days 95% confidence interval
Untreated control  19  17–21 19 17–21
Unlabeled d9MAb  38  35–41 ND
0.37 MBq d9MAb  99  74–169 ND
0.37 MBq d8MAb  37  15–55 ND
1.85 MBq d9MAb ND
1.85 MBq d8MAb ND
7.4 MBq d9MAb 213 162–264 73 44–102
7.4 MBq d8MAb 161  92–230 45 13–77
22.2 MBq d9MAb 119 104–134 86 19–153
22.2 MBq d8MAb 129  37–221 47 26–90

87% of the animals were still alive after 300 days.

75% of the animals were still alive at 300 days. ND, not determined.