Figure 7.
Anti‐OX40 monoclonal antibody (mAb) in combination with radiotherapy induces immunological memory. Mice 50–90 days after complete remission by anti‐OX40 mAb in combination with radiotherapy (treated mice) or aged‐matched untreated mice were injected intradermally with viable 1 × 106 Lewis lung carcinoma‐ovalbumin cells each in contralateral (left) flanks. (a) Antitumor activities and (b) survival induced by tumor rechallenge are shown. The bars indicate the mean ± SE of nine treated mice (open circles) and six untreated mice (closed circles). Data are presented as the mean ± SE. Similar results were obtained in two separate experiments. *P = 0.003.