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. 2007 Oct 22;99(2):187–194. doi: 10.1111/j.1349-7006.2007.00644.x

Figure 2.

Figure 2

Schematic representation of the protein structure of members of the xeroderma pigmentosum group F (XPF) nuclease family in mammals.( 32 , 33 ) Interactions of the subunits are mediated by C‐terminal helix‐hairpin‐helix (HhH) domains. Both XPF and ERCC1 contain C‐terminal tandem HhH domains (HhH2). XPF contains an N‐terminal helicase‐like domain, whereas Mus81 does an N‐terminal HhH domain instead. Both XPF and Mus81 contain the nuclease domains harboring conserved metal‐binding residues of a VERKxxxD motif. Remnants of nuclease domains are present in the middle domain of ERCC1.