Figure 3.

Regulation of Rad51 by tyrosine kinases. When DNA is damaged by ionizing radiation, ATM activates c‐Abl, whereby Rad51 is phosphorylated.^{( 37 )} epidermal growth factor receptor (EGFR) upregulates Rad51 in response to ionizing radiation by an unknown mechanism.^{( 45 )} BCR/ABL‐related fusion tyrosine kinases (FTKs) arising from chromosomal translocation in cancer and FLT3 ITD mutations activate the transcriptional activator STAT5, which upregulates Rad51.^{( 38} , ³⁹ , ⁴³ , ^{44 )} BCR/ABL also phosphorylates Rad51.^{( 38 )}