Figure 4.

Effect of blocking the Rho signal transduction pathway in RhoA‐transfected cell invasion. (a) When RhoA‐transfected SKOV3 cells were treated with C3 exoenzyme, Y27632, Lovastatin or Pravastatin for 22 h, the GTP‐binding form of RhoA was decreased. (b) Treatment with C3 exoenzyme, Y27632, Lovastatin or Pravastatin suppressed the number of invaded cells. The invasive capacity of RhoA‐transfected cells depended on Rho signaling. Data are expressed as the mean ± SEM of three separate experiments in triplicate wells. *P < 0.01 versus control cells with RhoA‐transfected cells.