Table 3.

Comparison of the immunoexpression of tumor necrosis factor (TNF)‐α, interleukin (IL)‐6, mutated (mt) p53 and p21 in three groups of breast samples

Variable	IL‐6					mtp53					p21
	Positive		Negative		P‐value	Positive		Negative		P‐value	Positive		Negative		P‐value
	n	%	n	%		n	%	n	%		n	%	n	%
Benign fibrocystic lesions (n = 17)
Positive	6	35.3 †	9	52.9		11	64.7 †	4	23.5		12	70.6 †	3	17.6
Negative	0	2	11.4	1		5.8	1	5.8	1		5.8	1	5.8
TNF‐α					0.514					0.514					0.426
In situ carcinoma (n = 20)
Positive	10	50 ‡	10	50		17	85 ‡	3	15		15	75 ‡	5	25
Negative	0	0	0	0		0	0	0	0		0	0	0	0
TNF‐α					NA					NA					NA
Infiltrating carcinoma (n = 45)
Positive	32	71.1 §	2	4.4		31	68.8 §	3	6.6		32	71.1 §	2	4.4
Negative	8	17.7	3	6.6		6	13.3	5	11.1		9	20	2	4.4
TNF‐α					0.085					0.014					0.247

^† Three patients were simultaneously positive for the four proteins (TNF‐α, IL‐6, mtp53 and p21).

^{‡ ‡} Eight patients were simultaneously positive for the four proteins.

^{§ §} Thirty patients were simultaneously positive for the four proteins. NA, not applicable.