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. 2006 Sep 25;97(12):1298–1307. doi: 10.1111/j.1349-7006.2006.00331.x

Figure 3.

Figure 3

Examples of methylation analysis of CpG islands at the promoter area of hPER3 gene. The sequence shown corresponds to the ‐336~‐389 to the transcriptional start site of hPER3 gene. (a) The cytosines remains intact in the Sss I‐treated, sodium bisulphate‐modified DNA. (b) All the cytosines convert to thymines in a PER3‐U positive case. (c) A CML patient showed significantly reduced expression of hPER3 with all the Cs in CpG dinucleotides remains as C in the sodium bisulphate‐modified DNA. (d) and (e) CML patients showed different levels of reduced hPER3 expression, and their modified DNA showed some methylated CpG sites C and some partially methylated C/T.