Figure 3.

Peroxisome proliferator‐activated receptor γ (PPARγ) inhibition reduces migration of PDAC cells. Cell migrations were estimated from transwell migration assays, in which migrated cells are stained violet and membrane pores can be seen as white dots. Relative to control‐treated cells, (a) Capan‐1 and (c) Panc‐1 cell migration decreased significantly and in a dose‐dependent manner in response to increasing concentrations of PPARγ inhibitor T0070907 (*P < 0.05). (b,d) Significant decreases in cell migration were also observed in PPARγ small interfering RNA (siRNA)‐transfected cells relative to control siRNA‐transfected cells.