Figure 3.

Formation of 8‐OH‐dG in HaCaT cells treated with ultraviolet (UV) A or psoralen plus UVA (PUVA). HaCaT cells were incubated with 100 ng/mL 8‐MOP and irradiated with various doses of UVA. The data represent the mean ± SD of four to five experiments. *P < 0.05, **P < 0.001, compared without UVA and with 8‐MOP. #P < 0.01, compared without UVA and 8‐MOP. MPD, minimal phototoxic doses. Skin was exposed to UVA 2 h after the ingestion of 8‐MOP tablets. The MPD is defined as the dose that induced minimally perceptible erythema 72 h after irradiation. ⁽³⁵⁾ Treatment: oral PUVA therapy doses for psoriasis vulgaris. ⁽³⁵⁾