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Plasma pharmacodynamics of sorafenib on day 28 of cycle 1
| 100 mg (n = 3) | 200 mg (n = 12) | 400 mg (n = 6) | 600 mg (n = 5) | |
|---|---|---|---|---|
| pERK+ (%) | 44.8 (10.3) | 43.6 (15.4) | 64.1 (29.6) | 57.5 (12.4%) |
| Adrenomedullin (fmol/mL) | 2.18 (0.62) † | 1.90 (0.67) | 2.97 (1.67) | 2.23 (0.61) |
Standard deviation is in parentheses.
pERK+ (phosphorylated ERK+) is expressed as percentage of positive cells in peripheral blood mononuclear cells.
n = 2.
