Table 1.

Characterization of 23 genome-wide significant obstructive sleep apnea loci

Chr	Position	Ref	Alt	RSIDS	Nearest Genes	Consequence	Info	Fin.enr*	MAF	MAF Cases	MAF Control	β	P Value	BMI-adjusted P Value
1	96567092	C	CT	rs34013490	PTBP2	Intergenic	0.99	0.97	0.66	0.67	0.66	0.05	6.33 × 10−9	3.91 × 10−7
2	102507453	A	C	rs76229479	SLC9A4	Intron	0.99	0.70	0.10	0.09	0.10	−0.08	2.64 × 10−9	4.97 × 10−10
3	132779050	C	T	rs114106239	NPHP3-ACAD11	Intron	0.98	2.43	0.04	0.03	0.04	−0.12	1.19 × 10−8	1.40 × 10−4
3	169159948	A	T	rs181010833	MECOM	Intron	0.99	210.62	0.04	0.03	0.04	−0.12	1.52 × 10−8	2.69 × 10−4
4	47311502	C	CA	rs34925548	GABRB1	Intron	0.98	1.19	0.70	0.69	0.70	−0.05	1.12 × 10−8	7.15 × 10−4
6	7746430	T	C	rs60700772	BMP6	Intron	0.99	1.02	0.22	0.23	0.22	0.05	2.20 × 10−8	1.18 × 10−5
7	69980355	A	G	rs11981973	AUTS2	Intron	1.00	1.03	0.18	0.19	0.18	0.06	4.72 × 10−10	3.94 × 10−5
7	75029963	A	C	rs17148727	RCC1L	Intron	0.97	1.00	0.68	0.67	0.68	−0.05	1.02 × 10−8	2.40 × 10−3
9	76652155	G	A	rs679880	PRUNE2	Noncoding transcript exon	0.99	0.92	0.75	0.75	0.74	0.05	2.53 × 10−8	4.36 × 10−5
9	125375595	C	T	rs10986730	GAPVD1	Upstream gene	0.99	1.23	0.52	0.51	0.53	−0.05	1.16 × 10−9	3.12 × 10−6
10	18302297	G	A	rs113955098	CACNB2	Intron	0.98	3.26	0.07	0.06	0.07	−0.10	3.38 × 10−10	1.01 × 10−4
10	100866753	G	T	rs61873510	PAX2	Intergenic	0.98	0.86	0.30	0.31	0.30	0.05	3.28 × 10−8	1.12 × 10−3
11	28365912	G	A	rs6484367	METTL15	Intron	0.99	0.99	0.50	0.51	0.50	0.05	1.13 × 10−9	4.00 × 10−6
12	56632124	A	C	rs59333125	BAZ2A	Intron	0.99	1.13	0.08	0.08	0.08	−0.08	1.32 × 10−8	1.28 × 10−5
12	97359374	C	T	rs10507084	NEDD1	Intergenic	0.99	3.03	0.18	0.19	0.18	0.06	8.23 × 10−11	1.22 × 10−7
12	107586546	C	T	rs2016950	BTBD11	Intron	0.99	1.33	0.16	0.15	0.16	−0.06	4.13 × 10−8	4.48 × 10−5
14	79424334	C	T	rs2370982	NRXN3	Intron	1.00	1.12	0.24	0.25	0.24	0.05	7.97 × 10−9	8.14 × 10−3
16	53771295	C	A	rs11075985	FTO	Intron	1.00	0.98	0.43	0.45	0.43	0.08	2.15 × 10−26	2.59 × 10−5
16	73774720	C	G	rs13333522	PSMD7	Intron	0.99	1.08	0.53	0.53	0.53	0.04	4.06 × 10−8	–
19	45679046	T	A	rs10423928	GIPR	Intron	1.00	1.19	0.26	0.25	0.26	−0.05	7.55 × 10−9	3.20 × 10−1
20	52363114	G	C	rs4809902	ZFP64	Intron	1.00	0.78	0.23	0.22	0.23	−0.06	1.51 × 10−9	2.59 × 10−5
20	59073311	C	T	rs140896965	PRELID3B	Regulatory region	0.99	9.68	0.05	0.04	0.05	−0.11	1.11 × 10−9	6.40 × 10−2
23	155574640	G	A	rs5940397	TMLHE	Intron	1.00	1.01	0.75	0.77	0.75	0.05	2.05 × 10−10	9.70 × 10−7

Definition of abbreviations: Alt = alternate allele; Chr = chromosome; POS = genomic position in build hg38; Ref = reference allele; Info = imputation quality score; MAF = minor allele frequency.

Effect sizes and allele frequencies are reported in terms of alternate allele.

^*Finnish enrichment, computed using the Genome Aggregation Database data comparing Finnish versus other European populations.