Fig. 1. The Acan^CreERT2 mouse targets all compartments of the IVD and GP.

(A to D) Representative images of immunofluorescent (IF) staining for RFP within mid-sagittal sections of caudal AcanCre^−/−;Ai14 and AcanCre^+/−;Ai14 reporter mice 3 days and 3 months following tamoxifen IP injections. (E and F) Images of IF staining for RFP within mid-sagittal sections of lumbar AcanCre^−/−;Ai14 and AcanCre^+/−;Ai14 reporter mice 3 months following tamoxifen IP injections. NP, AF, EP, and GP compartments are delineated (white dashed lines).