Figure 1.

Receiver operating characteristic curve analysis of frameshift mutation comparison between high microsatellite instability and mismatch repair-deficient patients and healthy participants. The receiver operating characteristic curve was generated by comparing the number of frameshift mutations detected between high microsatellite instability and Lynch syndrome patients and healthy participants. Pooled samples were excluded in this analysis. A) All 122 targets in the panel were included in the analysis. B, C, D) Receiver operating characteristic curve modeling analysis: By removing those targets, frameshift mutations were also detected in healthy participants (B, 66 targets), and by further removing those targets frameshift mutations were detected in ≤2 patients (C, 49 targets) or in ≤5 patients (D, 20 targets). AUC = area under the curve; CI = confidence interval.