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[Preprint]. 2024 May 30:rs.3.rs-4438402. [Version 1] doi: 10.21203/rs.3.rs-4438402/v1

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(A) Representative histological sections of lung cancer were stained with anti-CD45, anti-CD8a, or anti-CD11c antibodies. Lung cancer engrafted with KPLCLS-minOVA showed significant CD45+ immune cell infiltration compared to lung cancer induced by Tamoxifen injection (KP cancer). The tumor derived from KPLCLS-minOVA exhibits the infiltration of CD8a and CD11c immune cells. (B) KPLCLS-minOVA lung cancers were stained with anit-CD11c (brown) and anti-GFP (red) and showed intracellular GFP+ signals. (C) Flow cytometry analysis demonstrates that CD172+ conventional dendritic cell type 2 (cDC2) cells engulf ZsGreen+ KPLCLS-minOVA cancer cells, whereas XCR1+ cDC1 cells show minimal uptake of cancer cells. Scale bar: 100 μm.