TABLE A2.
Structured Diagnosis Codes and Synonyms Used for Identifying irAEs/Potential irAEs
| Sign or Symptom | Diagnosis Codes | Synonyms |
|---|---|---|
| Adrenal insufficiency | 255.5,E27.40,E27.49,E89.6,E27.3 | adrenal_insufficiency, hypoadrenalism, adrenal_gland_hypofunction |
| Anemia | 285.9,D64.9,280.9,D50.9,281.9,285.22,406636013,D64.89,D63.0,285.3,D64.81,285.8,D50.8,283.9,284.89,283.0,285.0,D53.1,D59.9,D59.1,D61.9,283.19,D46.4,2694725011,D61.1,D46.20,D59.0,D64.1,D61.09,D59.2,2694501018,D64.3,D64.2 | anemia, disorders_anemia, anemia_nos, anaemia |
| Arthralgia | M25.511,M25.512,M79.671,719.40,M79.672,M25.50,M25.571,M25.572,M79.662,M79.661,M25.519,M79.673,M25.541,M79.643,M25.542,M25.579,484753013,M79.669,1230691015,M26.629,M26.622,719.41,719.42,719.43,719.44,719.45,719.46,719.47,719.49 | polyarthralgia, arthralgias, polyarthralgias, arthralgia, joint_aches, joint_pain, aches_joint |
| Arthritis | M19.90,274.9,714.0,716.90,714.9,M06.9,M12.9,M06.4,7278014,M16.9,116082011,M10.00,M15.0,M00.9,M05.9,M13.80,M06.80,M13.861,113692012,M13.862,M11.9,M06.00,M11.861,M12.80,M13.811,M13.89,M02.9,M11.831,M13.841,M13.812,M13.851,M11.832,M13.871,M06.041,M13.842,M02.89,M06.042,M11.871,M06.031,M06.032,M06.09,M06.89,M05.79,M05.60,M05.80,M05.70,M05.69,M05.742,M06.849,M05.741,M06.011,M06.839,M06.012,M05.762,711.01,712.30,715.95,715.96,715.97,M05.141 | arthritis, articular_inflammatory_disease, skeletal_joint_inflammation |
| Aseptic meningitis | G03.0 | aseptic_meningitis, acute_aseptic_meningitis |
| Autoimmune diabetes | 250.01,E10.9,E10.65,197984010,E10.649,E10.21,E10.10,E10.40,E10.42,E10.319,E10.621,E10.622,E10.69,E10.22,E10.43,E10.311,E10.59,E10.51,E10.11,E10.3599,E10.3293,E10.3292,E10.3213,250.51,250.61,250.81 | autoimmune_diabetes |
| Colitis | 558.9,K52.9,556.9,K51.90,K52.89,K52.1,K51.00,009.1,K52.3,K52.832,558.1,K52.831,107644019,K52.839,K51.50,106758018,558.2,K51.20,556.6,107643013,K52.0,K52.29,353418019,K51.80,K51.911,K51.918,K52.82,1222282012,K51.914,K51.511,K51.919,K51.811,K51.819 | colitis, colitis_disease, colonic_inflammation, colon_inflammation, colitides |
| Dry mouth | 527.7,K11.7,R68.2 | xerostomia, dry_mouth |
| Encephalitis | G04.90,G04.81,75325010,G04.00 | encephalopathic, brain_inflammation, encephalitis |
| Enteritis | 558.9,K52.9,535.60,555.9,K29.80,555.0,K50.90,555.1,K50.00,558.1,K52.0,K50.80,535.61,K29.81 | enterocolitis, duodenitis, ileitis, enteritis, small_intestinal_enteritis, small_intestinal_inflammation, enteritides, small_intestine_inflammation |
| Hepatitis | 070.54,573.3,571.40,571.42,K75.4,K70.10,206586011,K73.9,K75.3,B15.9,B17.10,K71.2,K73.2,K71.3,K75.2,K71.6,B16.9,63183013,K73.8,K73.0,353589015 | hepatitis, liver_inflammation, acute_hepatitis, hepatitides, chronic_hepatitis, chronic_persistent_hepatitis |
| Hyperthyroidism | 242.90,E05.90,E05.00,E05.80,57561015,E05.20,E05.10,2694980014,E05.91,E06.2,E05.81,E05.21,E05.41 | hyperthyroidism, overactive_thyroid, hyperthyroid, hyperthyreosis |
| Hypophysitis | 253.2 | hypophysitis, hypophysitides, pituitary_inflammation, pituitary_gland_inflammation |
| Hypothyroidism | E03.9,68268011,492839019,244.8,E03.8,178809013,91116012,E03.2,137019010,244.9 | hypothyroidism, hypothyreosis, underactive_thyroid, thyroid_deficiency, thyroid_insufficiency |
| Mucositis | 528.00,K12.30,528.01,528.09,K12.32,K12.33,K12.39,K92.81,1782682019,K12.31 | mucositis, mucositides, mucosa_inflammation, mucosal_inflammation |
| Myocarditis | 429.0,I51.4,D86.85,I40.9,I40.1,84844011,I40.8,I41 | myocarditis, myocarditis_nos, inflammatory_cardiomyopathy, myocarditides, myocardial_inflammation, myocardium_inflammation |
| Nephritis | N10,583.81,N12,N05.9,583.89,N11.8,580.89,47940012 | nephritis, nephritis_nos, kidney_inflammation, inflammation_of_kidneys, nephritides |
| Neuropathy | G62.9,355.9,354.2,337.9,353.0,710.9,355.8,351.0,G90.9,356.8,G62.89,355.0,G51.0,053.19,G56.22,G56.21,378.54,G56.13,357.6,1480220018,B02.29,G90.09,G56.11,H46.9,377.39,351.9,G57.01,G56.12,G62.0,G56.23,G57.61,G52.9,G50.9,355.2,G51.9,352.6,G56.31,H47.093,G57.32,H47.012,G57.92,G57.31,G57.91,H47.011,G56.32,H47.013,H47.092,G57.93,H81.22,G99.0,H47.091,G57.00,G52.8,G57.90,G56.91,H47.019,G70.9,G56.92,G56.81,G54.9,357.3,G63,G61.9,G52.7,G62.2,G52.2,G62.81,G57.30,G57.21,G54.3,B02.23,G61.89,G56.93,158470017,G58.0,H47.099,352.4,G61.82,1777429019,G13.0,H49.22,195776019,H49.21,H49.11,35332011,H49.01,H49.12,H49.20,H49.02,G57.23,H49.00,G62.82,345513016,H49.23,H49.13,E09.42,357.9 | polyneuropathy, neuropathy |
| Pancreatitis | 577.0,K86.1,K85.9,K85.90,303630010,K85.10,K85.80,K85.91,K85.8,K85.81,K85.30,K85.31 | acute pancreatitis, pancreatitis, edema_pancreatic_parenchymal, peripancreatic_fat_necrosis, acute_edematous_pancreatitis, pancreatitis_nos, pancreas_inflammation, pancreatitides |
| Pneumonitis | 515,J84.9,J84.89,508.1,508.0,J70.1,516.32,J70.0,314740018,M34.81,J84.114,M05.10,J84.113,J84.17 | pneumonitis, pneumonitides, lung_parenchyma_inflammation |
| Rash | 782.1,R21,709.8,693.0,L27.0,L27.1,2764045019,1226128015 | rash |
| SCAR events | 709.8,709.2,695.89,695.9,L90.5,L53.9,I96,L13.9,L51.9,694.8,L26,L51.1,L51.3 | severe cutaneous adverse reaction, stevens johnson syndrome, sjs, acute generalised exanthematous pustulosis, agep, dress, drug-induced hypersensitivity syndrome, SCAR events, bullous_haemorrhagic_dermatosis, cutaneous_vasculitis, dermatitis_bullous, dermatitis_exfoliative, dermatitis_exfoliative_generalised, bullous_dermatitis, generalized_exfoliative_dermatitis, exfoliative_dermatitis, drug_reaction_with_eosinophilia_and_systemic_symptoms, epidermal_necrosis, erythema_multiforme, erythrodermic_atopic_dermatitis, exfoliative_rash, generalised_bullous_fixed_drug_eruption, oculomucocutaneous_syndrome, sjs_ten_overlap, skin_necrosis, target_skin_lesion, toxic_epidermal_necrolysis, toxic_skin_eruption |
| Thrombocytopenia | 287.5,D69.6,D69.59,287.49,287.31,D69.3,443796011,1227080015,M31.1,294383018,199491013 | thrombocytopenia, thrombocytopenic_disorders, low_platelet_count, thrombopenia, ttp |
| Thyroiditis | 245.2,E06.3,245.9,E06.9,36884017,E06.1,E06.5,E06.0,136211012,E06.4,E06.2,292420015 | thyroiditis, thyroiditis_nos, disease_thyroiditis, thyroid_gland_inflammation |
| Uveitis | 364.3,H20.9,H20.00,H20.13,H20.11,H20.022,H20.021,H30.93,H20.023,360.12,H30.92,H30.91,H30.90,H44.113,206795017,2842394015,H44.112 | uveitis, disease_uveitis, uvea_inflammation, uveitis_nos, uveitides, uveal_inflammation |
| Vasculitis | 447.6,447.8,I77.6,I77.89,417.8,M31.6,I28.8,M31.30,L95.8,L95.9,I67.7,M31.0,D89.1,M31.8,L95.0 | vasculitis, angiitides, angiitis, vasculitis_syndrome |
| Vitiligo | 709.01,L80 | vitiligo, vitiligo_vulgaris |
Abbreviations: irAE, immune-related adverse event; SCAR, severe cutaneous adverse reaction.