Table 2.
Response in pediatric patients with aGvHD among the included papers.
| Author | N. of pts | S (%) | OR (%) | L(%) | OR(%) | G(%) | OR (%) | III-IV (%) | OR in III-IV (%) | ORR % | CR % | NR % | TF % | TTR days | TTCR days |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Khandelwal | 11 | 7 (53) | 2 (28) | 2 (15) | 0 | 12 (92) | 3 (25) | 11 (84) | NA | 45 | 9 | 18 | 36 | NA | NA |
| González Vicent | 13 | 8 (61) | (75ORR 33 CR) | 4 (31) | (73ORR18 CR) | 6(46) | 77 ORR31 CR | 13 (100) | (77) | 77 | 31 | 23 | NA | NA | NA |
| Uygun | 13 | NA | NA | NA | NA | 11 (85) | (82) | 11 (85) | (82) | 85 | 69 | 15 | NA | NA | NA |
| Laisne | 29 | 18 (62) | 5/6 with isolated skin (83) | 4 (14) | NA | 20 (69) | 15/20 (75) | 22 (76) | 16/22 (72) | 72.4 | 65.5 | NA | 27.6 | 69 | 41 |
| Meng | 3 | 6 (50) | (100) | 9 (75) | (78) | 8 (67) | (87) | 6 (50) | 5/6 (83) | 83.3 | 58.3 | 0 | 17 | NA | NA |
| Moiseev | 17 | NA | NA | NA | NA | NA | NA | NA | NA | 75 | 63 | 25 | NA | 20 | 53 |
| Mozo | 8 | 1 (12) | (100) | 0 | NA | 7 (87) | 6/7 (86) | (100) | (87.5) | 87.5 | 37 | 12 | NA | 28 | NA |
| Yang | 17 | NA | NA | NA | NA | NA | NA | 13 (76) | NA | 64.7 | 29.4 | 0 | 35 | 28 (to best resp) | NA |
| Wei | 4 | NA | NA | NA | NA | NA | NA | NA | NA | 86.9 | 56.5 | 13 | NA | 5 | NA |
| Marcuzzi | 6 | NA | NA | NA | NA | NA | NA | 2 (33) | (100) | 100 | 100 | NA | NA | 21 | NA |
CR complete remission, G gut, L liver, N. number, NA not applicable, NR non response, OR overall response, ORR overall response rate, S skin, TF treatment failure, TTCR time to complete response TTR, time to response.