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. 2024 Jun 7;15:4867. doi: 10.1038/s41467-024-48925-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Average speed between day 49 and 112 shows amelioration in SOD1^G93A;En1^cre mice from P56, (b) step frequency from P77, (c) stride length from P84, and (d) peak acceleration from P77. P49: WT N = 12, En1^cre N = 6, SOD1^G93A N = 8, SOD1^G93A;En1^cre N = 7, P56: WT N = 9, En1^cre N = 4, SOD1^G93A N = 7, SOD1^G93A;En1^cre N = 6, P63: WT N = 11, En1^cre N = 9, SOD1^G93A N = 8, SOD1^G93A;En1^cre N = 7; P70-P105: WT N = 10, En1^cre N = 8, SOD1^G93A N = 8, SOD1^G93A;En1^cre N = 7, P112: WT N = 9, En1^cre N = 8, SOD1^G93A N = 8, SOD1^G93A;En1^cre N = 7. At P112 (e) speed is higher in SOD1^G93A;En1^cre compared to SOD1^G93A (One-way ANOVA and Dunnett’s post hoc, SOD1^G93A;En1^cre vs SOD1^G93A P = 3e-10), as well as (f) step frequency (One-way ANOVA and Dunnett’s post hoc, P = 1.1e-08), (g) stride length (One-way ANOVA and Dunnett’s post hoc, P = 5e-04), and (h) peak acceleration (One-way ANOVA and Dunnett’s post hoc, P = 0.0087) (WT N = 9; SOD1^G93A N = 8, En1^cre N = 8, SOD1^G93A;En1^cre N = 7). (i) Stick figures depict intralimb coordination. Two full cycles are visualized for SOD1^G93A and SOD1^G93A;En1^cre mice upon injections. Stance phase blue, swing phase green. Changes in joint angles were analyzed for (j) hip, (k) knee, (l) ankle and (m) foot angles. Significant changes were found for the ankle (One-way ANOVA and Dunnett’s post hoc, P = 8.5e-07), and foot (One-way ANOVA and Dunnett’s post hoc, P = 2e-07) angles upon ESYT1 overexpression (WT = 9, SOD1^G93A N = 8, En1^cre N = 8, SOD1^G93A;En1^cre N = 7). n, o Markers for kinematic and weight support analysis. p Weight support is successfully recovered in SOD1^G93A;En1^cre compared to SOD1^G93A (One-way ANOVA and Dunnett’s post hoc, P = 0.0015). All quantifications were performed in triplicates, graphs show mean values ± SEM, average values in (e–h, j–m, and p) are shown in black, technical triplicates in gray. Source data are provided as a Source Data file.