Table 3.

Emergent Themes With Associated Descriptions and Exemplar Quotes From Patients Interviewed on Acceptability of Out-of-Clinic Administration of Long-acting Injectable Antiretroviral Therapy Across 3 Urban Human Immunodeficiency Virus Clinics, August 2020–July 2021

Theme	Thematic Summary	Exemplar Quote(s)
Thematic domain 1: drivers of acceptability
Subtheme 1 (ST1)	Convenience and ease of use motivated appeal of out-of-clinic injections	ST1: “Some people don’t have transportation places. So, you know, even better they can do it they self at home … So, not just like the convenience of it, but literally if you’re having trouble getting there, then that's a good option for you.” (30 y, Black gay male, Atlanta)
Subtheme 2 (ST2)	Prior experience with injectables impacts acceptability	ST2: “The idea of self-administering it is a bit of a turnoff. And it's probably memories of my brother dealing with his [diabetes] … I’m assuming there’d be a lot of ancillary things …You’ve got your two vials. You’ve got your syringe, your needle, your alcohol prep pads … There's a lot of prep and a lot of [steps] to get it done.” (58 y, White gay male, San Francisco)
Subtheme 3 (ST3)	Fear of self-inflicted pain hinders self-injection acceptability	ST3: “If you’re going to have a painful shot like that, you should be laying down … because when you say it could be less than a penicillin, more than a flu, that to me says to me it's going to be more like the penicillin and you're just not saying it yet … If I stick myself in the butt with a needle and then hurting myself, that's kind of like along the lines of suicide.” (65 y, multiracial gay male, San Francisco)
Subtheme 4 (ST4)	Fear of dependence on others and HIV disclosure hinders injection by a partner, friend, or family member	ST4: “If I had [a partner], I would want to train them—I would teach them how to do it, and since I don’t, that would not be an option. I can’t train my dog to do it for me, and he’s the only one that lives with me. It's kind of like—as far as a neighbor, I used to think the whole world needs to know [about my HIV status], and now I’m finding out it's not.” (62 y, White heterosexual male, San Francisco)
Thematic domain 2: implementation considerations
Cross-cutting theme 1 (CCT1)	Balancing convenience and confidentiality concerns, implication for product packaging	CCT1-1: “Now, I do live in a safe environment where people know that I’m HIV-positive so it wouldn’t bother me. If it's something you had to store in like a refrigerator, I wouldn’t mind that either. But if I wasn’t in such a secure environment—if the medication had to be stored in something cool—I wouldn’t be comfortable with it because I wouldn’t want people to know.” (46 y, Black gay male, Atlanta) CCT1-2: “When it comes to the disposing of the needles, I think they should be mailed out with some sort of biohazardous box … some way to get rid of the needles [safely] that’s not like you just throw them away in the trash can and then somebody finds them. And you don’t have to explain to them that you’re not, like, shooting up with drugs, that you’re, like—that you’re actually taking medicine. Like, I don’t want to have to explain that empty needle in the trashcan to my grandmother, you know?” (27 y, Black gay male, Chicago) CCT1-3: “Just so you know, simple [text message] reminder … Hey, you’re due for your shot within this period, please confirm when you took it, or please confirm that you got this message and you’re aware of it.” (52 y, White gay male, San Francisco)
Cross-cutting theme 2 (CCT2)	Balancing professionalism and self-efficacy concerns, implication for product attributes	CCT2-1: “But I’m not up for poking myself … It's a risk because you don’t know if you’re going to do it right or if you’re going to hit a bone. I mean, you could injure yourself.” (57 y, Latino bisexual male, San Francisco) CCT2-2: “Like the way they did with Humira was like the first time or the first couple of times, you came into the office and then the individual, the nurse watched you do it so they could say, that is how you do it or here's how better to do it.” (61 y, White gay male, San Francisco) CCT2-3: “If they made it like an EpiPen that was already loaded with the dose, and all you had to do was jam it into your butt. But if it's a process where you’ve got a vial like you have insulin, and you’ve got to draw and fill up the syringe and knock out the air bubbles and all of that kind of crap … I think it gets a little bit more challenging and it makes me a little bit more nervous that I might screw something up.” (58 y, White gay male, San Francisco)

Abbreviation: HIV, human immunodeficiency virus.