Table 1.
Participant characteristics, demographics, functional connectivity, and APOE genotype (n = 122)
| Variable Name | Mean±SD |
|---|---|
| Age | 69.50±7.34 (range 55–89) |
| Sex (n, female%) | 84 (68.9) |
| APOE2 carriers (n, 2/3%) | 2 (1.6) |
| APOE2 carriers (n, 2/4%) | 2 (1.6) |
| APOE3 homozygotes (n, 3/3%) | 62 (50.8) |
| APOE4 carriers (n, 3/4 or 4/4%) | 50 (41.0) |
| APOE4 homozygotes | 4 (3.3) |
| Unknown or missing | 2 (1.6) |
| Race/ethnicity | |
| Asian (n, %) | 20 (16.4) |
| Native Hawaiian or pacific islander | 0 (0) |
| American Indian or Alaska native | 0 (0) |
| Black or African American | 1 (0.8) |
| White | 87 (71.3) |
| Other | 2 (1.6) |
| Unknown or missing | 12 (9.8) |
| Dementia Rating Scale | 140±0.4 |
| Aβ42/40 ratio | 0.036±0.007 |
| GFAP (pg/ml) | 160.08±78.62 |
| Neurofilament light chain (pg/ml) | 19.28±8.05 |
| CAN functional connectivity (RRC) | 0.052±0.038 |
| Parasympathetic CAN functional connectivity (RRC) | 0.045±0.039 |
| Sympathetic CAN functional connectivity (RRC) | 0.036±0.033 |
CAN: Central autonomic network, RRC: fisher transformed ROI-to-ROI connectivity matrix, pg/ml: Picograms per milliliter, GFAP: Astrocytic intermediate filament glial fibrillary acidic protein