| Criteria |
Description |
Score |
Patient’s Score |
| Time to onset of infection |
5-90 days of drug start |
+2 |
|
| <5 or > 90 days of drug start |
+1 |
| ≤15 days from drug cessation |
+1 |
| Course of reaction after drug cessation |
Decrease ≥50% within 8 days |
+3 |
|
| Decrease ≥50% within 30 days |
+2 |
| Not application |
+1 |
| No information/Decrease ≥50% after 30 days |
0 |
| Recurrent increase |
-2 |
| Risk factors |
Age ≥55 |
+1 |
|
| |
Alcohol use |
+1 |
| Concomitant drugs |
Time to onset incompatible |
0 |
|
| Time to onset compatible but unknown reaction |
-1 |
| Time to onset compatible but known reaction |
-2 |
| Role proved in this case |
-3 |
| None or information not available |
0 |
| Non drug related causes |
All causes reasonably ruled out |
+2 |
|
| 6 causes of group 1 ruled out |
+1 |
| 5 or 4 causes of group 1 ruled out |
0 |
| Less than 4 causes of group 1 ruled out |
-2 |
| Non drug cause highly probable |
-3 |
| Previous information on drug |
Reaction unknown |
0 |
|
| Reaction published but unlabelled |
+1 |
| Reaction labelled in product characteristics |
+2 |
| Response to re-administration |
Positive |
+3 |
|
| Compatible |
+1 |
| Negative |
-2 |
| Not available or Not interpretable |
0 |
