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. Author manuscript; available in PMC: 2024 Jun 9.
Published in final edited form as: Nat Biomed Eng. 2024 Apr 19;8(5):593–610. doi: 10.1038/s41551-024-01194-7

Extended Fig. 3. Varying the length of the side chain of the polypeptide regulates immunogenicity via ER stress-mediated mtDNA release and effector functions in macrophages.

Extended Fig. 3.

(a) Chemical structures of polypeptides with side chains of different lengths. P1 induced (b) ER stress and (c) mtDNA release in BMDMs more strongly than did P3 (mid-length) and PS (short length) (n=3, mean±SD), ordinary one-way ANOVA. P1 improved (d) phagocytosis of EO771 breast cancer cells and (e) cross-presentation of the model antigen SIINFEKL-H2Kb to a greater extent than did P3 and P1 (n=3, mean±SD), ordinary one-way ANOVA. (f) Expression of genes for pro-inflammatory cytokines was affected by the length of side chains in the polypeptides (n=3, mean±SD), ordinary one-way ANOVA.