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. Author manuscript; available in PMC: 2024 Jun 9.
Published in final edited form as: Nat Biomed Eng. 2024 Apr 19;8(5):593–610. doi: 10.1038/s41551-024-01194-7

Extended Fig. 8. TLR9 activation is required to recruit tumor-infiltrating T cells by stimulating IRF7 signaling in tumor-homing APCs treated with P1+αPD1.

Extended Fig. 8.

(a) P1+αPD1 treatment promoted p-IRF7 nuclear translocation in macrophages and DCs in WT but not in TLR9−/− mice; scale bar, 30 μm; unpaired Student’s t test in comparison to the indicated conditions (n=8 independent images, mean±SD). (b) P1+αPD1 treatment of TLR9−/− mice blocked recruitment of both CD4+ and CD8+ T cells into tumors; scale bar, 20 μm; unpaired Student’s t test in comparison to the indicated conditions (n=6 independent images, mean±SD). Numbers of cells in the immunofluorescence images were counted by ImageJ software.