Fig. 5. SOD3 suppresses IL-2 and concomitant IFN-γ production by T cells.

a, b The proportion of CD8⁺ or CD4⁺ T cells producing IL-2 upon treatment with SOD3 was significantly reduced in in vitro experiments, n = 3. c, d Treatment with SP600125, a selective JNK inhibitor, led to a decrease in the proportion of IL-2-producing CD8⁺ or CD4⁺ T cells, n = 3. e and f The proportion of IFN-γ⁺CD122⁺ T cells but not that of CD122⁺ T cells expanded in the SOD3^−/− mice, n = 4 (e, f). a–f Two-tailed student’s t test was used to test for significant differences between two groups. g Serum levels of IFN-γ was analysis by neutralizing Abs for IL-2, n = 3–4. Histograms present the mean ± SD. Source data are provided as a Source Data file.