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. 2024 Jun 8;15:4901. doi: 10.1038/s41467-024-49215-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a The sis BGC, structure of sistertide A1 and suggested structure of sistertide A2, and antibacterial potential of S. albus/pCZSIS crude extract. The AviMeCys motif is shown in pink. D-amino acids are shown in red. Other noncanonical amino acid are shown in blue. b The keb BGC. c UPLC-HRMS analysis of Streptomyces kebangsaanensis DSM42048 wild-type strain (i), S. albus/pCZKEB (ii, heterologous expression of keb BGC) and S. albus/pJTU2554 (iii, empty vector). d Suggested structures of kebanetides. e Bioactivity of kebanetides against M. luteus. f Chimeric precursor with the maturase from keb BGC. g UPLC-HRMS analysis of new-to-nature analog from construct keb-syn2. Source data are provided in MassIVE (10.25345/C5PC2TM3Q).