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. 2024 Jun 8;15:4901. doi: 10.1038/s41467-024-49215-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a The growth kinetics of S. aureus with massatide A and massatide B. b Massatide A did not resulted in lysis. (Con. is the control with no compound.) c Time-dependent killing of S. aureus (10×MIC vancomycin, 10×MIC massatide A). Time points are graphed as the mean c.f.u. ± s.d (n = 3). The experiment was performed in biological triplicate. d Resistance acquisition during serial passaging in the presence of sub-MIC levels. Vancomycin and norfloxacin were used as control. e The survival rate in acute toxicity study in vivo (Blank and all the experimental groups are overlapped). f The survival rate in septicemia model using MRSA treated with massatide A (10 mg/kg and 30 mg/kg groups are overlapped). The relevant Source data for Fig. 5a, c, e, f are provided as a Source Data file.