Table 1.

Description of main model variables of compartmental concentrations

Name	Description
$b H T$	Blood histidine.
$c H T$	Cytosolic histidine.
$c H T_{p o o l}$	Cytosolic histidine pool.
$c H A$	Cytosolic histamine.
$v H A_{r}$	Reserve of vesicular histamine.
$v H A$	Vesicular histamine.
$B_{H A}$	Bound histamine to receptors.
$B_{5 H T}$	Bound serotonin to receptors.
$e H A$	Extracellular histamine.
$T$	Regulator of G protein in receptors.
$T^{*}$	Activated regulator of G protein in receptors.
$G$	G protein in receptors.
$G^{*}$	Activated G protein in receptors.
$b t r p$	Blood tryptophan.
$t r p$	Cytosolic tryptophan.
$t r p_{p o o l}$	Cytosolic tryptophan pool.
$b h 4$	Tetrahydrobiopterin.
$b h 2$	Dihydrobiopterin.
$N A D P^{+}$	Nicotinamide adenine dinucleotide phosphate.
$N A D P H$	Reduced nicotinamide adenine dinucleotide phosphate.
$5 H T P$	5-hydroxytryptophan or oxitriptan.
$c 5 H T$	Cytosolic 5-hydroxytryptamine or serotonin.
$5 H I A A$	5-Hydroxyindoleacetic acid
$v 5 H T_{r}$	Reserve of vesicular serotonin.
$v 5 H T$	Vesicular serotonin.
$e 5 H T$	Extracellular serotonin.
$g 5 H T$	Glial cytosolic serotonin.
$g H T$	Glial histidine.
$g H T_{p o o l}$	Glial histidine pool.
$g H A$	Glial histamine.
$E S C I T$	Escitalopram.
$F M H$	(S) α-fluoromethylhistidine.