Figure 1.

HDL nanobiologic platform technology. HDL is reconstituted from apolipoprotein A1 (apoA-I) and phospholipids. The HDL scaffold can be customized to include (A) amphiphilic or lipophilic imaging labels or (B) a diagnostically active nanocrystal core, rendering HDL nanobiologics suitable for precision and molecular imaging purposes. In addition, these labeling strategies can be deployed to understand HDL nanobiologics in vitro and in vivo behavior, with optical methods, nuclear imaging, as well as CT and MRI. (C) Payloads for therapeutic purposes can be incorporated in HDL nanobiologics. (D) HDL nanobiologics engage immune cells through apoA-I’s binding capacity for the adenosine triphosphate-binding cassette transporter A1 (ABCA1) and the scavenger receptor type B-1 (SR-BI).