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Under normal conditions, release signals will recruit JMJD6 to BRD4, allowing RNA polymerase II to release from paused state. However, when ARGLU1 is present, it will compete with BRD4 for binding to JMJD6, preventing recruitment of JMJD6 and JMJD6-associated removal of pause-enhancing histone marks, retaining HEXIM1 at the promoter and keeping RNA polymerase II in paused state.
